The aim of PRODECIS is to support Radiation Oncologists with the decision making between two valid treatment plans (photon or proton radiotherapy). The estimated clinical complications and the cost-efficiency of the treatment options are calculated by using validated toxicity prediction and cost-efficiency models.
Computation services are separated into three levels:dosimetric, toxicity and cost effectiveness. On the dosimetric level, Dose–Volume Histogram (DVH) calculation algorithms are used to extract relevant DVH metrics from both photon and proton plans that are required for the second toxicity computation level. On the toxicity level, several validated Normal Tissue Complication Probability (NTCP) models are used. These models are compliant to the TRIPOD Type 4 standard. On the cost effectiveness level, a published Markov model is used to assess the number of Quality Adjusted Life Years (QALY) and costs resulting from each treatment.
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